Core outcome set for multiple myeloma
A standardized set of outcomes that should be measured and reported in all clinical studies and practice for multiple myeloma, developed with input from patients and healthcare professionals to ensure relevance and consistency.
At a glance
Use when
Designing clinical trials or observational studies in multiple myeloma; developing clinical guidelines; standardizing outcome reporting in routine care
Avoid when
When focusing on exploratory or hypothesis-generating research with novel endpoints; when the study aims to evaluate outcomes outside the scope of the core set
Inputs
Input from patients, clinicians, and researchers via Delphi surveys and consensus meetings; existing literature on myeloma outcomes
Outputs
A standardized list of core outcomes to be measured in all multiple myeloma clinical studies and practice
How it works
This core outcome set (COS) for multiple myeloma was updated and validated through a European consensus process involving patients, clinicians, and researchers. It defines a minimum set of outcomes to be collected in all multiple myeloma clinical trials and routine care, ensuring comparability across studies and alignment with patient priorities. The development followed COMET Initiative guidelines, using Delphi surveys and consensus meetings.
- Project
- H2O
- Funding
- IMI
- Project status
- Ongoing
- HTA domains
- Clinical Effectiveness, Patient and Social Aspects
- Technology
- Non-specific
- Assumptions
- That harmonizing outcome measurement improves evidence quality and patient relevance; that stakeholder consensus leads to broader acceptance
- Strengths
- Includes patient perspectives; enhances comparability across studies; supports regulatory and clinical decision-making; developed using rigorous consensus methodology
- Limitations
- May require adaptation for specific study designs; does not specify measurement instruments; implementation may vary across settings
- Geographic & clinical scope
- Geographic Scope: Europe Clinical Scope: Multiple Myeloma
- Also known as
- COS for multiple myeloma, Multiple Myeloma Core Outcome Set
Questions this answers
- › What outcomes should always be measured in multiple myeloma studies?
- › How can we make results from different myeloma trials more comparable?
- › What patient-reported outcomes are essential in myeloma care?
- › Which clinical endpoints are agreed upon by experts and patients?
- › How is patient-centeredness incorporated into myeloma research outcomes?
- › What minimum data should be collected in every myeloma clinical assessment?
Related methods
Similar by meaning
Beta record. Generated from the primary source via AI extraction and independent audit, pending final human review.